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【结 构 式】 
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【分子编号】34318 【品名】N-cyano-N'-[4-(1H-imidazol-4-yl)phenyl]iminoformamide 【CA登记号】 |
【 分 子 式 】C11H9N5 【 分 子 量 】211.22616 【元素组成】C 62.55% H 4.29% N 33.16% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)This compound can be obtained through two different ways from 4-(4-aminophenyl)-1H-imidazole (I): 1) By condensation of compound (I) with ethyl N-isopropylformimidate (II) in ethanol. 2) The reaction of compound (I) with ethyl N-cyanoformimidate (III) gives N'-cyano-N-(4-1H-imidazol-4-ylphenyl)formamidine (IV), which is treated with isopropylamine (V).
| 【1】 Cereda, E.; Donetti, A.; Del Soldato, P.; Bergamoschi, M.; Imidazolylphenyl amidines, pharmaceutical compositions containing same and use thereof. EP 0053407; ES 8207147; ES 8207148; ES 8207149; ES 8207150; ES 8207151; ES 8207152; GB 2088375; JP 57120575; US 4386099; US 4465841 . |
| 【2】 Donetti, A.; et al.; (Imidazoylphenyl)formamidines. A structurally novel class of potent histamine H2-receptor antagonists. J Med Chem 1984, 27, 3, 380-386. |
| 【3】 Serradell, M.N.; de Angelis, L.; Castaner, J.; Mifentidine. Drugs Fut 1984, 9, 11, 825. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 34316 | 4-(1H-imidazol-4-yl)phenylamine; 4-(1H-imidazol-4-yl)aniline | C9H9N3 | 详情 | 详情 | |
| (II) | 34317 | ethyl isopropyliminoformate | C6H13NO | 详情 | 详情 | |
| (III) | 24747 | ethyl cyanoiminoformate | C4H6N2O | 详情 | 详情 | |
| (IV) | 34318 | N-cyano-N'-[4-(1H-imidazol-4-yl)phenyl]iminoformamide | C11H9N5 | 详情 | 详情 | |
| (V) | 23933 | 2-Propanamine; Isopropylamine | 75-31-0 | C3H9N | 详情 | 详情 |
Extended Information