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【结 构 式】

【分子编号】34253

【品名】1-cyclopropyl-1-ethanone oxime

【CA登记号】

【 分 子 式 】C5H9NO

【 分 子 量 】99.1326

【元素组成】C 60.58% H 9.15% N 14.13% O 16.14%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

This compound can be obtained in two different ways: 1) The reaction of cyclopropylmethyl ketone oxime (II) with epibromohydrin (A) in THF containing NaH gives O-[2,3-epoxypropyl]cyclopropylmethyl ketone oxime (III), which is treated with excess tert-butylamine (C) in ethanol yielding the final compound. 2) By condensation of cyclopropylmethyl ketone (I) with 3-(aminooxy)-N-tert-butyl-2-hydroxypropanamine (B) in ethanol.

1 Leclerc, G.; Bouzoubaa, M.; Andermann, G.; Ethers and oxime ethers of alkylamino alcohols as medicaments and novel products, and processes for their preparation. AU 1167283; EP 0087378; FR 2521856; JP 58154538; US 4766151 .
2 Schwartz, J.; Bieth, N.; Leclerc, G.; Synthesis and beta-adrenergic blocking activity of a new aliphatic oxime ethers. J Med Chem 1980, 23, 6, 620.
3 Castaner, J.; Serradell, M.N.; Falintolol oxalate. Drugs Fut 1984, 9, 7, 510.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 29679 2-(bromomethyl)oxirane 3132-64-7 C3H5BrO 详情 详情
(B) 34255 1-(aminooxy)-3-(tert-butylamino)-2-propanol C7H18N2O2 详情 详情
(I) 12435 Acetylcyclopropane; 1-Cyclopropyl-1-ethanone; Cyclopropylmethylketone 765-43-5 C5H8O 详情 详情
(II) 34253 1-cyclopropyl-1-ethanone oxime C5H9NO 详情 详情
(III) 34254 1-cyclopropyl-1-ethanone O-(2-oxiranylmethyl)oxime C8H13NO2 详情 详情
(C) 17895 2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine 75-64-9 C4H11N 详情 详情
Extended Information