(3aR,4R,5R,6aR)-4-[(benzyloxy)methyl]-6-bromo-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]hexahydro-2(1H)-pentalenone -Drug Synthesis Database

【结构式】

【分子编号】34235

【品名】(3aR,4R,5R,6aR)-4-[(benzyloxy)methyl]-6-bromo-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]hexahydro-2(1H)-pentalenone

【CA登记号】

【分子式】C₂₂H₂₉BrO₄

【分子量】437.37386

【元素组成】C 60.42% H 6.68% Br 18.27% O 14.63%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVII)

The protection of bromoketol (VI) with dihydropyran and p-toluene sulfonic acid in methylene chloride gives the corresponding tetrahydropyranyl derivative (XVII), which is debrominated with tributyltin hydride as usual yielding (VIII), already obtained.

参考文献中间体

合成目标

【1】 Hayashi, M.; Konishi, Y.; Arai, Y.; 6,9-Methano-PGI2 analogues. CH 639360; DE 2912409; FR 2422635; GB 2017699; IT 1113341; US 4479966 .
【2】 Kottegoda, S.R.; Serradell, M.N.; Adaikan, P.G.; Castaner, J.; ONO-41483. Drugs Fut 1984, 9, 11, 833.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VI)	34225	(3aR,4S,5S,6aR)-4-[(benzyloxy)methyl]-6-bromo-5-hydroxyhexahydro-2(1H)-pentalenone	C₁₆H₁₉BrO₃	详情	详情
(VIII)	34227	(3aS,4R,5R,6aR)-4-[(benzyloxy)methyl]-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]hexahydro-2(1H)-pentalenone	C₂₂H₃₀O₄	详情	详情
(XVII)	34235	(3aR,4R,5R,6aR)-4-[(benzyloxy)methyl]-6-bromo-5-[(tetrahydro-2H-pyran-2-yloxy)methyl]hexahydro-2(1H)-pentalenone	C₂₂H₂₉BrO₄	详情	详情

Extended Information