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【结 构 式】

【分子编号】34215

【品名】1-[4-(benzyloxy)anilino]-3-methoxy-2-propanol

【CA登记号】

【 分 子 式 】C17H21NO3

【 分 子 量 】287.35868

【元素组成】C 71.06% H 7.37% N 4.87% O 16.7%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

The condensation of p-benzyloxyaniline (I) with 1-chloro-2-hydroxy-3-methoxypropane (II) in ethanol, followed by cyclization ot the resulting amino alcohol (III) with ethyl carbonate (A) in toluene in the presence of CH3ONa and debenzylation affords a phenolic 2-oxazolidinone (V), which is alkylated with m-cyanobenzyl bromide (VI) to give cimoxatone.

1 Ancher, J.F.; Bourgery, G.; Dostert, P.; Douzon, C.; Guerret, P.; Lacour, A.; Laglois, M.; Nouvelles oxazolidinones, oxazolidinethiones et pyrrilidinones, leur procédé de préparation et leur application en thérapeutique. FR 2428032; JP 55051064; JP 56167666 .
2 Ancher, J.F.; Cimoxatone. Drugs Fut 1984, 9, 6, 412.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 17470 diethyl carbonate; diethylcarbonate 105-58-8 C5H10O3 详情 详情
(I) 22460 4-(benzyloxy)aniline; 4-(benzyloxy)phenylamine C13H13NO 详情 详情
(II) 34214 1-chloro-3-methoxy-2-propanol 4151-97-7 C4H9ClO2 详情 详情
(III) 34215 1-[4-(benzyloxy)anilino]-3-methoxy-2-propanol C17H21NO3 详情 详情
(IV) 28690 (5R)-3-[4-(benzyloxy)phenyl]-5-(methoxymethyl)-1,3-oxazolidin-2-one C18H19NO4 详情 详情
(V) 28682 (5R)-3-(4-hydroxyphenyl)-5-(methoxymethyl)-1,3-oxazolidin-2-one C11H13NO4 详情 详情
(VI) 13244 alpha-Bromo-m-tolunitrile; 3-(Bromomethyl)benzonitrile 28188-41-2 C8H6BrN 详情 详情
Extended Information