2-[4-[(1S,3S)-3-(4-fluorophenyl)-6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]-1-ethanol -Drug Synthesis Database

【结构式】

【分子编号】34141

【品名】2-[4-[(1S,3S)-3-(4-fluorophenyl)-6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]-1-ethanol

【CA登记号】

【分子式】C₂₂H₂₄F₄N₂O

【分子量】408.4390528

【元素组成】C 64.7% H 5.92% F 18.61% N 6.86% O 3.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIV)

Compound (XII) is finally condensed with piperazine-ethanol (XIII) in refluxing butanone. The separation of the trans isomer is performed by precipitation of the oxalate, treatment with dimethyl-amine in water and extraction with ether.

参考文献中间体

合成目标

【1】 Bogeso, K.P.; Neuroleptic activity and dopamine-uptake inhibition in 1-piperazino-3-phenylindans. J Med Chem 1983, 26, 7, 935-947.
【2】 Castaner, J.; Serradell, M.N.; Tefludazine. Drugs Fut 1984, 9, 5, 346.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(XIIa)	34139	(1R,3S)-3-chloro-1-(4-fluorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1H-indene		C₁₆H₁₁ClF₄	详情	详情
(XIIb)	34140	(1S,3S)-3-chloro-1-(4-fluorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1H-indene		C₁₆H₁₁ClF₄	详情	详情
(XIII)	21893	2-(1-piperazinyl)-1-ethanol; 1-piperazineethanol; 1-(2-Hydroxyethyl)piperazine	103-76-4	C₆H₁₄N₂O	详情	详情
(XIV)	34141	2-[4-[(1S,3S)-3-(4-fluorophenyl)-6-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]-1-piperazinyl]-1-ethanol		C₂₂H₂₄F₄N₂O	详情	详情

Extended Information