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【结 构 式】 
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【分子编号】34127 【品名】2-(tert-butylamino)-1-(3,4-dihydroxyphenyl)-1-ethanone 【CA登记号】 |
【 分 子 式 】C12H17NO3 【 分 子 量 】223.27192 【元素组成】C 64.55% H 7.67% N 6.27% O 21.5% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of 3,4-dihydroxyphenyl-tert-butylaminomethyl ketone (I) with sodium ethoxide in DMF gives the corresponding disodium salt, which without isolation is condensed with p-toluyl chloride (A) to yield 3,4-bis(p-toluyloxy)phenyl-tert-butylaminomethyl ketone hydrochloride (II); this salt is then reduced with H2 over Pd/C in ethanol or with sodium borohydride in methanol.
| 【1】 Minatoya, H.; et al.; Ester von alpha-Aminomethyl-3-(hydroxy- oder hydroxymethyl)-4-hydroxybenzyl-alkoholen und Verfahren zu ihrer Herstellung. DE 2015573; FR 2042295; GB 1298771 . |
| 【2】 Castaner, J.; Weetman, D.F.; Bitolterol. Drugs Fut 1976, 1, 10, 454. |
Extended Information