acetaldehyde N-(7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene)hydrazone -Drug Synthesis Database

【结构式】

【分子编号】34102

【品名】acetaldehyde N-(7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene)hydrazone

【CA登记号】

【分子式】C₁₇H₁₅ClN₄

【分子量】310.78576

【元素组成】C 65.7% H 4.86% Cl 11.41% N 18.03%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XI)

The reaction of 7-chloro-5-phenyl-2-hydrazino-1,3-dihydro-3H-1,4-benzodiazepine (X) with refluxing acetaldehyde (C) gives 7-chloro-5-phenyl-2-ethylydenhydrazino-1,3-dihydro-3H-1,4-benzodiazepine (XI), which is cyclized by refluxing in chloroform (10.5 h) or by heating at 160-72 C (10 min).

参考文献中间体

合成目标

【1】 Hester, J.B. Jr.; Benzodiazepines and the manufacture thereof. CH 574425; DE 2242938; FR 2154474; GB 1382605; JP 48034894 .
【2】 Castaner, J.; Chatterjee, S.S.; Alprazolam. Drugs Fut 1976, 1, 12, 551.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(X)	34101	7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one hydrazone		C₁₅H₁₃ClN₄	详情	详情
(XI)	34102	acetaldehyde N-(7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-ylidene)hydrazone		C₁₇H₁₅ClN₄	详情	详情
(C)	11974	Acetaldehyde	75-07-0	C₂H₄O	详情	详情

Extended Information