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【结 构 式】

【分子编号】34069

【品名】 

【CA登记号】

【 分 子 式 】C14H18O7S

【 分 子 量 】330.35872

【元素组成】C 50.9% H 5.49% O 33.9% S 9.71%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

Prepared by reacting 2-methoxy-5-methylsulfonylbenzoic acid (I) with isobutyl chloroformate (A) in dioxane to give the corresponding anhydride (II), which is finally condensed with N,N-diethylethylenediamine (B).

1 Bulteau, G.; Acher, J.; Process for preparing benzamides. CH 585699; DE 2327192; GB 1394563; JP 49085037 .
2 Neuman, M.; Prous, J.R.; Tiapride. Drugs Fut 1976, 1, 2, 88.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(B) 12420 N-(2-Aminoethyl)-N,N-diethylamine; N,N-Diethylethylene-diamine; N(1),N(1)-Diethyl-1,2-ethanediamine 100-36-7 C6H16N2 详情 详情
(A) 13423 1-[(Chlorocarbonyl)oxy]-2-methylpropane; Isobutyl chloroformate;isobutyl carbonochloridate 543-27-1 C5H9ClO2 详情 详情
(I) 34068 2-methoxy-5-(methylsulfonyl)benzoic acid 50390-76-6 C9H10O5S 详情 详情
(II) 34069   C14H18O7S 详情 详情
Extended Information