【结 构 式】 |
【分子编号】34063 【品名】N-(2-phenoxyphenyl)methanesulfonamide; 2-Phenoxymethanesulfonanilide 【CA登记号】51765-51-6 |
【 分 子 式 】C13H13NO3S 【 分 子 量 】263.31716 【元素组成】C 59.3% H 4.98% N 5.32% O 18.23% S 12.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(I)Compound can be prepared in three different ways: 1) By nitration of 2-phenoxymethanesulfonanilide (I) with nitric acid in acetic acid. 2) By condensation of 2-phenoxy-4-nitroaniline (II) with methanesulfonyl chloride in pyridine. 3) By condensation of 2-bromo-4-nitromethanesulfonanilide (III) with phenol (A) by means of KOH and pyridine in benzene.
【1】 Moore, G.; Harrington, J.K.; Substituted 2-phenoxy alkanesulfonanilides. US 3840597 . |
【2】 2-Phenoxy alkyl sulphonalides. DE 2333643; FR 2190460; GB 1435755; JP 57136560; JP 57140712 . |
【3】 Castaner, J.; Chatterjee, S.S.; R-805. Drugs Fut 1976, 1, 3, 145. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(A) | 23540 | Phenol | 108-95-2 | C6H6O | 详情 | 详情 |
(I) | 34063 | N-(2-phenoxyphenyl)methanesulfonamide; 2-Phenoxymethanesulfonanilide | 51765-51-6 | C13H13NO3S | 详情 | 详情 |
(II) | 34064 | 4-nitro-2-phenoxyaniline; 4-nitro-2-phenoxyphenylamine | C12H10N2O3 | 详情 | 详情 | |
(III) | 34065 | N-(2-bromo-4-nitrophenyl)methanesulfonamide | C7H7BrN2O4S | 详情 | 详情 |
Extended Information