(4-fluorophenyl)(2-thienyl)methanone -Drug Synthesis Database

【结构式】

【分子编号】34018

【品名】(4-fluorophenyl)(2-thienyl)methanone

【CA登记号】579-49-7

【分子式】C₁₁H₇FOS

【分子量】206.2403832

【元素组成】C 64.06% H 3.42% F 9.21% O 7.76% S 15.55%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

The reaction of 2-thiophenecarbonyl chloride (I) with fluorobenzene (A) by means of AlCl3 gives (4-fluorophenyl)(2-thienyl)ketone (II), which is then condensed with diethyl methylmalonate (B) by means of NaH in benzene-HMPA to yield diethyl 2-methyl-2-[4-(2-thienylcarbonyl)phenyl]malonate (III); this product is finally hydrolyzed and partially decarboxylated with refluxing aqueous NaOH.

参考文献中间体

合成目标

【1】 Van Daele, P.G.H.; et al.; Synthesis of alpha-methyl-4-(2-thienylcarbonyl)benzene acetic acid, suprofen and derivatives. Arzneim-Forsch Drug Res 1975, 25, 10, 1495-1501.
【2】 Castaner, J.; Chatterjee, S.S.; Suprofen. Drugs Fut 1976, 1, 3, 148.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(A)	17466	Fluorobenzene	462-06-6	C₆H₅F	详情	详情
(B)	30310	diethyl 2-methylmalonate	609-08-5	C₈H₁₄O₄	详情	详情
(I)	14103	2-Thiophenecarbonyl chloride	5271-67-0	C₅H₃ClOS	详情	详情
(II)	34018	(4-fluorophenyl)(2-thienyl)methanone	579-49-7	C₁₁H₇FOS	详情	详情
(III)	34019	diethyl 2-methyl-2-[4-(2-thienylcarbonyl)phenyl]malonate		C₁₉H₂₀O₅S	详情	详情

Extended Information