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【结 构 式】 
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【分子编号】33968 【品名】2-[(3-methylphenoxy)methyl]oxirane; 3-methylphenyl 2-oxiranylmethyl ether 【CA登记号】 |
【 分 子 式 】C10H12O2 【 分 子 量 】164.20408 【元素组成】C 73.15% H 7.37% O 19.49% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The condensation of 3-methylphenol (I) and epichlorohydrin (II) by means of NaOH gives 1,2-epoxy-3-(3-methylphenoxy)propane (III), which is then condensed with 3,4-dimethoxyphenylethylamine (V) by heating their mixture at 95-100 C.
| 【1】 Holmes, A.; Meyer, R.F.; New aminoalkanol compounds and methods for their production. FR 2163486; GB 1344976; JP 48067232 . |
| 【2】 Milton, L.H.; et al.; Cardioselective beta-adrenergic blocking agents. 1. 1-[3,4-(dimethoxyphenethyl)amino]-3-aryloxy-2-propanols. J Med Chem 1975, 18, 2, 148-152. |
| 【3】 Castaner, J.; Weetman, D.F.; Bevantol. Drugs Fut 1977, 2, 8, 500. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 17793 | m-cresol; m-Methylphenol | 108-39-4 | C7H8O | 详情 | 详情 |
| (II) | 10146 | Epichlorohydrin; 2-(Chloromethyl)oxirane | 106-89-8 | C3H5ClO | 详情 | 详情 |
| (III) | 33968 | 2-[(3-methylphenoxy)methyl]oxirane; 3-methylphenyl 2-oxiranylmethyl ether | C10H12O2 | 详情 | 详情 | |
| (V) | 10098 | 2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine | 120-20-7 | C10H15NO2 | 详情 | 详情 |
Extended Information