1-chloro-3-(3-methylphenoxy)-2-propanol -Drug Synthesis Database

【结构式】

【分子编号】33967

【品名】1-chloro-3-(3-methylphenoxy)-2-propanol

【CA登记号】

【分子式】C₁₀H₁₃ClO₂

【分子量】200.66472

【元素组成】C 59.86% H 6.53% Cl 17.67% O 15.95%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

The condensation of 3-methylphenol (I) with epichlorohydrin (II) by means of a catalytic amount of piperidine gives 1-(3-methylphenoxy)-3-chloro-2-propanol (IV), which is then condensed with 3,4-dimethoxyphenylethylamine (V) by heating their mixture at 95-100 C.

参考文献中间体

合成目标

【1】 Holmes, A.; Meyer, R.F.; New aminoalkanol compounds and methods for their production. FR 2163486; GB 1344976; JP 48067232 .
【2】 Milton, L.H.; et al.; Cardioselective beta-adrenergic blocking agents. 1. 1-[3,4-(dimethoxyphenethyl)amino]-3-aryloxy-2-propanols. J Med Chem 1975, 18, 2, 148-152.
【3】 Castaner, J.; Weetman, D.F.; Bevantol. Drugs Fut 1977, 2, 8, 500.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	17793	m-cresol; m-Methylphenol	108-39-4	C₇H₈O	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(IV)	33967	1-chloro-3-(3-methylphenoxy)-2-propanol		C₁₀H₁₃ClO₂	详情	详情
(V)	10098	2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine	120-20-7	C₁₀H₁₅NO₂	详情	详情

Extended Information