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【结 构 式】 
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【分子编号】33965 【品名】2-(benzyloxy)-2-oxoethyl 4-[(Z)-2-(4-chlorobenzoyl)-2-(4-methoxyphenyl)hydrazono]pentanoate 【CA登记号】 |
【 分 子 式 】C28H27ClN2O6 【 分 子 量 】522.98496 【元素组成】C 64.31% H 5.2% Cl 6.78% N 5.36% O 18.36% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)3) The reaction of p-methoxyphenylhydrazine (V) with benzyl levulinate (IV) in acetic acid gives the corresponding hydrazone (VI), which, without isolation, is cyclized to benzyl 5-methoxy-2-methylindole-3-acetoxyacetate (VII) at 80 C in acetic acid. Then this compound is benzoylated with p-chlorobenzoyl chloride (B) by means of NaH in DMF. 4) The hydrazone (VI) can also be benzoylated first giving the corresponding hydrazone (VIII), which is then cyclized at 80 C in acetic acid.
| 【1】 Boltze, K.; Brendler, O.; Dell, H.-D.; Jacobi, H.; Novel substituted indole compound, process for the preparation and therapeutic compositions containing it.. DE 2234651; ES 416877; FR 2192828; JP 49043970; US 3910952 . |
| 【2】 Leeson, P.A.; Castaner, J.; Acemetacin. Drugs Fut 1977, 2, 7, 423. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 10295 | p-Chlorobenzoyl chloride; 4-Chlorobenzoyl chloride | 122-01-0 | C7H4Cl2O | 详情 | 详情 |
| (I) | 33962 | 2-(benzyloxy)-2-oxoethyl 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate | C28H24ClNO6 | 详情 | 详情 | |
| (IV) | 33963 | 2-(benzyloxy)-2-oxoethyl 4-oxopentanoate | C14H16O5 | 详情 | 详情 | |
| (V) | 12688 | 4-Hydrazinophenyl methyl ether; 1-(4-Methoxyphenyl)hydrazine | 3471-32-7 | C7H10N2O | 详情 | 详情 |
| (VI) | 33964 | 2-(benzyloxy)-2-oxoethyl 4-[(Z)-2-(4-methoxyphenyl)hydrazono]pentanoate | C21H24N2O5 | 详情 | 详情 | |
| (VII) | 33966 | 2-(benzyloxy)-2-oxoethyl 2-(5-methoxy-2-methyl-1H-indol-3-yl)acetate | C21H21NO5 | 详情 | 详情 | |
| (VIII) | 33965 | 2-(benzyloxy)-2-oxoethyl 4-[(Z)-2-(4-chlorobenzoyl)-2-(4-methoxyphenyl)hydrazono]pentanoate | C28H27ClN2O6 | 详情 | 详情 |
Extended Information