2-bromo-N-(4-chlorophenyl)-N-(2,2,2-trifluoroethyl)acetamide -Drug Synthesis Database

【结构式】

【分子编号】33852

【品名】2-bromo-N-(4-chlorophenyl)-N-(2,2,2-trifluoroethyl)acetamide

【CA登记号】

【分子式】C₁₀H₈BrClF₃NO

【分子量】330.5315696

【元素组成】C 36.34% H 2.44% Br 24.17% Cl 10.73% F 17.24% N 4.24% O 4.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVI)

N-bromoacetyl compound (IV) can also be obtained by bromoacetylation of (XV) with bromoacetyl bromide (B) in refluxing benzene affording 4-chloro-N-bromoacetyl-N-(2,2,2-trifluoroethyl)aniline (XVI), followed by a Friedel-Crafts reaction with benzoyl chloride by means of AlCl3.

参考文献中间体

合成目标

【1】 Topliss, J.G.; 2-Polyfluoroweralkyl benzophenones. US 3641147 .
【2】 Topliss, J.G.; 1-Polyhalogenoalkyl-2-oxo-1,3-dihydro-2H-14-benzodiazepines. US 3429874 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(D)	10463	Benzoyl chloride	98-88-4	C₇H₅ClO	详情	详情
(B)	14005	2-Bromoacetyl bromide; Bromoacetyl bromide	598-21-0	C₂H₂Br₂O	详情	详情
(IV)	33849	N-(2-benzoyl-4-chlorophenyl)-2-bromo-N-(2,2,2-trifluoroethyl)acetamide		C₁₇H₁₂BrClF₃NO₂	详情	详情
(XV)	33475	N-(4-chlorophenyl)-N-(2,2,2-trifluoroethyl)amine; 4-chloro-N-(2,2,2-trifluoroethyl)aniline		C₈H₇ClF₃N	详情	详情
(XVI)	33852	2-bromo-N-(4-chlorophenyl)-N-(2,2,2-trifluoroethyl)acetamide		C₁₀H₈BrClF₃NO	详情	详情

Extended Information