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【结 构 式】 
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【分子编号】33728 【品名】2-phenylsuccinic acid 【CA登记号】635-51-8 |
【 分 子 式 】C10H10O4 【 分 子 量 】194.187 【元素组成】C 61.85% H 5.19% O 32.96% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIV)The reaction of 6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxol-6-one (I) with nitromethane by means of butylamine in refluxing toluene/methylcyclohexane/acetic acid gives the nitromethyl derivative (XIII), which is reduced with H2 over Pd/C in methanol to yield the previously described amine (VII). Amine (VII) can be condensed with 2-phenylsuccinic acid by means of acetyl chloride in refluxing xylene yielding directly the previously reported succinimide (X) as a mixture of the cis and trans racemic diastereomers.
| 【1】 Deshpande, M.N.; et al.; A scalable process for the novel antidepressant ABT-200. Org Process Res Dev 1998, 2, 6, 351. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 33715 | 8,9-dihydronaphtho[1,2-d][1,3]dioxol-6(7H)-one | C11H10O3 | 详情 | 详情 | |
| (VII) | 33724 | 6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxol-6-ylmethylamine; 6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxol-6-ylmethanamine | C12H15NO2 | 详情 | 详情 | |
| (X) | 33722 | 3-phenyl-1-(6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxol-6-ylmethyl)-2,5-pyrrolidinedione | C22H21NO4 | 详情 | 详情 | |
| (XII) | 33726 | 6-[(E)-nitromethylidene]-6,7,8,9-tetrahydronaphtho[1,2-d][1,3]dioxole | C12H11NO4 | 详情 | 详情 | |
| (XIII) | 33727 | 6-(nitromethyl)-8,9-dihydronaphtho[1,2-d][1,3]dioxole | C12H11NO4 | 详情 | 详情 | |
| (XIV) | 33728 | 2-phenylsuccinic acid | 635-51-8 | C10H10O4 | 详情 | 详情 |
Extended Information