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【结 构 式】 
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【分子编号】33679 【品名】(3aS,4R,7R,8R,9R,10R,11R,13R,15R,15aR)-1-(3,4-dichlorophenethyl)-4-ethyl-8-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-10-[[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl]oxy]-11-methoxy-3a,7,9,11,13,15-hexamethyldecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazole-2,6,14(1H,7H)-trione 【CA登记号】 |
【 分 子 式 】C46H72Cl2N2O13 【 分 子 量 】931.98876 【元素组成】C 59.28% H 7.79% Cl 7.61% N 3.01% O 22.32% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)N-Demethylation by treatment with iodine and sodium acetate under irradiation of a halogen lamp produced secondary amine (VIII). Finally, reductive condensation of (VIII) with cyclopentanone (IX) in the presence of sodium cyanoborohydride yielded the title cyclopentylamino compound.
| 【1】 Kaminski, M.A.; Crawford, B.W.; Dalton, C.R.; Mort, N.A.; Sauer, D.R.; Bruncko, M.; Greer, J.; Frey, L.M.; Randolph, J.; Haviv, F. (Abbott Laboratories Inc.); Macrolide LHRH antagonists. US 5955440; WO 9950275 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 33677 | (3aS,4R,7R,8R,9R,10R,11R,13R,15R,15aR)-1-(3,4-dichlorophenethyl)-10-[[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy]-4-ethyl-8-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-11-methoxy-3a,7,9,11,13,15-hexamethyldecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazole-2,6,14(1H,7H)-trione | C47H74Cl2N2O13 | 详情 | 详情 | |
| (VIII) | 33679 | (3aS,4R,7R,8R,9R,10R,11R,13R,15R,15aR)-1-(3,4-dichlorophenethyl)-4-ethyl-8-[[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy]-10-[[(2S,3R,4S,6R)-3-hydroxy-6-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl]oxy]-11-methoxy-3a,7,9,11,13,15-hexamethyldecahydro-2H-oxacyclotetradecino[4,3-d][1,3]oxazole-2,6,14(1H,7H)-trione | C46H72Cl2N2O13 | 详情 | 详情 | |
| (IX) | 15113 | cyclopentanone | 120-92-3 | C5H8O | 详情 | 详情 |
Extended Information