• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】33614

【品名】2-(4-isobutylphenyl)acetonitrile

【CA登记号】

【 分 子 式 】C12H15N

【 分 子 量 】173.25784

【元素组成】C 83.19% H 8.73% N 8.08%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

Several methods for obtaining this compoud have been described: 1) By treating the 4-isobutyl phenyl acetonitrile (I) with sodium amide and ethyl iodide, followed by the hydrolysis of the reaction product (II). 2) The reaction of the nitrile (I) with sodium ethoxide and diethyl carbonate leads to the cyanoacetic ester (III), which is treated with ethyl iodide; thus (IV) being obtained, the hydrolysis and decarboxylation of (IV) leads to the final acid. 3) The alkaline hydrolysis of the 4-isobutyl phenyl acetonitrile (I) leads to 4-isobutyl phenyl acetic acid (V). This product after treatment with Na in naphthalene and ethyl iodide (A) yields the required compound.

1 Aparicio, L.; et al.; Procedimiento para la obtencion del acido 2-(4'-isobutifenil)butirico. ES 427197; ES 435173; ES 435174 .
2 Aparicio, L.; Butibufen. Drugs Fut 1977, 2, 3, 156.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 10925 Iodoethane;ethyl iod 75-03-6 C2H5I 详情 详情
(I) 33614 2-(4-isobutylphenyl)acetonitrile C12H15N 详情 详情
(II) 33615 2-(4-isobutylphenyl)butanenitrile C14H19N 详情 详情
(III) 33616 ethyl 2-cyano-2-(4-isobutylphenyl)acetate C15H19NO2 详情 详情
(IV) 33617 ethyl 2-cyano-2-(4-isobutylphenyl)butanoate C17H23NO2 详情 详情
(V) 33618 2-(4-isobutylphenyl)acetic acid C12H16O2 详情 详情
Extended Information