• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】33534

【品名】4,6-dichloro-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone

【CA登记号】

【 分 子 式 】C9H11Cl2N3O2

【 分 子 量 】264.11076

【元素组成】C 40.93% H 4.2% Cl 26.85% N 15.91% O 12.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Compound can be prepared in two different ways: 1) The condensation of 4,5-dichloro-2-methyl-3-(2H)pyridazinone (I) with morpholine (A) in refluxing ethanol gives 2-methyl-4-chloro-5-morpholino-3(2H)-pyridazinone (II), which is then treated with sodium ethoxide in refluxing ethanol. 2) The reaction of 2-methyl-4,6-dichloro-5-morpholino-3(2H)pyridazinone (III) with sodium ethoxide in refluxing ethanol gives 2-methyl-4-ethoxy-5-morpholino-6-chloro-3(2H)-pyridazinone (IV), which is then reduced with H2 over Pd/C in THF.

1 Satoda, I.; et al.; JP 7224030 .
2 Satoda, I.; et al.; 2-Alkyl-4-alkoxy-5-morpholino-3-2H-pyridazinones and their method of preparation. GB 1351569 .
3 Satoda, I.; et al.; Verfahren zur Herstellung von 2-Alkyl-4-alkoxy-5-morpholino-3(2H)-pyridazinon. DE 2225218 .
4 Kishikawa, T.; Matsuo, T.; JP 7659882 .
5 Castaner, J.; Blancafort, P.; M-73101. Drugs Fut 1978, 3, 10, 756.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(A) 10388 Morpholine 110-91-8 C4H9NO 详情 详情
(I) 33532 4,5-dichloro-2-methyl-3(2H)-pyridazinone 933-76-6 C5H4Cl2N2O 详情 详情
(II) 33533 4-chloro-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone C9H12ClN3O2 详情 详情
(III) 33534 4,6-dichloro-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone C9H11Cl2N3O2 详情 详情
(IV) 33535 6-chloro-4-ethoxy-2-methyl-5-(4-morpholinyl)-3(2H)-pyridazinone C11H16ClN3O3 详情 详情
Extended Information