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【结 构 式】 
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【分子编号】33439 【品名】(6R,7R)-7-[[(2R)-8-ethyl-2-(4-hydroxyphenyl)-12-(4-nitrophenyl)-4,9,10-trioxo-11-oxa-3,5,8-triazadodec-1-anoyl]amino]-3-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 【CA登记号】 |
【 分 子 式 】C32H34N10O11S2 【 分 子 量 】798.81476 【元素组成】C 48.12% H 4.29% N 17.53% O 22.03% S 8.03% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XI)The condensation of (II) with the substituted phenylacetic acid (X) by means of ethyl chlorocarbonate gives the cephalosporin (XI), which is then cyclized by means of NaH in ethanol.
| 【1】 Saikawa, I.; et al. (Toyama Chemical Co., Ltd.); Process for preparation of novel penicilins and cephalosporins. JP 52036684 . |
| 【2】 Castaner, J.; Serradell, M.N.; Blancafort, P.; T-1551. Drugs Fut 1979, 4, 9, 675. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (II) | 32663 | (6R,7R)-7-amino-3-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 24209-38-9 | C10H12N6O3S2 | 详情 | 详情 |
| (X) | 33438 | (11R)-5-ethyl-11-(4-hydroxyphenyl)-1-(4-nitrophenyl)-3,4,9-trioxo-2-oxa-5,8,10-triazadodecan-12-oic acid | C22H24N4O9 | 详情 | 详情 | |
| (XI) | 33439 | (6R,7R)-7-[[(2R)-8-ethyl-2-(4-hydroxyphenyl)-12-(4-nitrophenyl)-4,9,10-trioxo-11-oxa-3,5,8-triazadodec-1-anoyl]amino]-3-[[(1-methyl-1H-1,2,3,4-tetraazol-5-yl)sulfanyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | C32H34N10O11S2 | 详情 | 详情 |
Extended Information