(4S)-4-[[3-[2-[(3S)-3-([[(1S)-1-phenylethyl]amino]methyl)pyrrolidinyl]ethyl]-2-(trimethylsilyl)-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one -Drug Synthesis Database

【结构式】

【分子编号】34472

【品名】(4S)-4-[[3-[2-[(3S)-3-([[(1S)-1-phenylethyl]amino]methyl)pyrrolidinyl]ethyl]-2-(trimethylsilyl)-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one

【CA登记号】

【分子式】C₃₀H₄₂N₄O₂Si

【分子量】518.77474

【元素组成】C 69.46% H 8.16% N 10.8% O 6.17% Si 5.41%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XVI)

An alternative process consisted in the palladium-catalyzed condensation of iodoaniline (VIII) with the acyl silane (XV), to produce the 2-silyl indole (XVI). Then, acid desilylation of (XVI), followed by treatment with oxalic acid yielded the title compound.

参考文献中间体

合成目标

【1】 Chen, C.-Y.; Larsen, R.D. (Merck & Co., Inc.); Palladium catalyzed indolization. US 5808064; WO 9806725 .

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VIII)	34466	(4S)-4-(4-amino-3-iodobenzyl)-1,3-oxazolidin-2-one	C₁₀H₁₁IN₂O₂	详情	详情
(XV)	34471	3-[(3S)-3-([[(1S)-1-phenylethyl]amino]methyl)pyrrolidinyl]-1-(trimethylsilyl)-1-propanone	C₁₉H₃₂N₂OSi	详情	详情
(XVI)	34472	(4S)-4-[[3-[2-[(3S)-3-([[(1S)-1-phenylethyl]amino]methyl)pyrrolidinyl]ethyl]-2-(trimethylsilyl)-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one	C₃₀H₄₂N₄O₂Si	详情	详情

Extended Information