benzyl 5-[acetyl(hydroxy)amino]pentylcarbamate -Drug Synthesis Database

【结构式】

【分子编号】33396

【品名】benzyl 5-[acetyl(hydroxy)amino]pentylcarbamate

【CA登记号】92700-68-0

【分子式】C₁₅H₂₂N₂O₄

【分子量】294.35076

【元素组成】C 61.21% H 7.53% N 9.52% O 21.74%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

The acetylation of (III) as before gives 1-carbobenzoxyamino-5-(N-acetylhydroxylamino)pentane (X), which is debenzylated as usual yielding 1-amino-5-(N-acetylhydroxylamino)pentane (XI). Finally, this compound is condensed with (V) to afford (VII).

参考文献中间体

合成目标

【1】 Prelog, V.; Walser, A.; 75. Stoffweschselprodukte con actinomyceten. Uber die synthese der ferrioxamine B und D1. Helv Chim Acta 1962, 45, 631-637.
【2】 Bickel, H.; et al.; 153. Stoffweschselprodukte von mikroorganismen. Zur henntnis von desferrioxamin B. Helv Chim Acta 1963, 46, 1385-89.
【3】 Blancafort, P.; Castaner, J.; Serradell, M.N.; Hopkins, S.J.; Liposome-Entrapped Desferrioxamine deferoxamine. Drugs Fut 1979, 4, 7, 500.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(III)	33389	benzyl 5-(hydroxyamino)pentylcarbamate		C₁₃H₂₀N₂O₃	详情	详情
(V)	33391	benzyl 5-(3,6-dioxo-1,2-oxazinan-2-yl)pentylcarbamate		C₁₇H₂₂N₂O₅	详情	详情
(VII)	33393	benzyl 5-[[4-([5-[acetyl(hydroxy)amino]pentyl]amino)-4-oxobutanoyl](hydroxy)amino]pentylcarbamate		C₂₄H₃₈N₄O₇	详情	详情
(X)	33396	benzyl 5-[acetyl(hydroxy)amino]pentylcarbamate	92700-68-0	C₁₅H₂₂N₂O₄	详情	详情
(XI)	33397	N-(5-aminopentyl)-N-hydroxyacetamide		C₇H₁₆N₂O₂	详情	详情

Extended Information