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【结 构 式】 
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【分子编号】33394 【品名】N(1)-[5-[acetyl(hydroxy)amino]pentyl]-N(4)-(5-aminopentyl)-N(4)-hydroxysuccinamide 【CA登记号】 |
【 分 子 式 】C16H32N4O5 【 分 子 量 】360.45404 【元素组成】C 53.31% H 8.95% N 15.54% O 22.19% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)The debenzylation of (VII) by hydrogenation with H2 over Pd/C gives 1-amino-6-hydroxy-16-(N-acetylhydroxylamino)-7,10-dioxo-6,11-diazahexadecane (VIII), which condensed with (V) as before yields 1-carbobenzoxyamino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(N-acetylhydroxylamino)-6,11,17,22-tetrazaheptaeicosane (IX). Finally, this compound is debenzylated by means H2 over Pd/C.
| 【1】 Bickel, H.; et al.; 153. Stoffweschselprodukte von mikroorganismen. Zur henntnis von desferrioxamin B. Helv Chim Acta 1963, 46, 1385-89. |
| 【2】 Prelog, V.; Walser, A.; 75. Stoffweschselprodukte con actinomyceten. Uber die synthese der ferrioxamine B und D1. Helv Chim Acta 1962, 45, 631-637. |
| 【3】 Blancafort, P.; Castaner, J.; Serradell, M.N.; Hopkins, S.J.; Liposome-Entrapped Desferrioxamine deferoxamine. Drugs Fut 1979, 4, 7, 500. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (V) | 33391 | benzyl 5-(3,6-dioxo-1,2-oxazinan-2-yl)pentylcarbamate | C17H22N2O5 | 详情 | 详情 | |
| (VII) | 33393 | benzyl 5-[[4-([5-[acetyl(hydroxy)amino]pentyl]amino)-4-oxobutanoyl](hydroxy)amino]pentylcarbamate | C24H38N4O7 | 详情 | 详情 | |
| (VIII) | 33394 | N(1)-[5-[acetyl(hydroxy)amino]pentyl]-N(4)-(5-aminopentyl)-N(4)-hydroxysuccinamide | C16H32N4O5 | 详情 | 详情 | |
| (IX) | 33395 | benzyl 6,17,28-trihydroxy-7,10,18,21,29-pentaoxo-6,11,17,22,28-pentaazatriacont-1-ylcarbamate | C33H54N6O10 | 详情 | 详情 |
Extended Information