[[(methylsulfanyl)carbothioyl]amino]methanesulfonic acid -Drug Synthesis Database

【结构式】

【分子编号】33374

【品名】[[(methylsulfanyl)carbothioyl]amino]methanesulfonic acid

【CA登记号】

【分子式】C₃H₇NO₃S₃

【分子量】201.29152

【元素组成】C 17.9% H 3.51% N 6.96% O 23.85% S 47.79%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

Compound 1-sulfamoylmethyltetrazol-5-thiol (IX) can also be obtained by reaction of (I) with CS2 and MeI by means of KOH in refluxing ethanol to give sulfomethyldithiocarbamic acid methyl ester (XIII), which is then cyclized with NaN3 in hot water.

参考文献中间体

合成目标

【1】 Berges, D.A.; 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins.. DE 2611270; FR 2304343; US 4048311 .
【2】 Castaner, J.; Serradell, M.N.; Thorpe, P.; Blancafort, P.; Cefonicid sodium. Drugs Fut 1979, 4, 9, 634.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	33363	aminomethanesulfonic acid	13881-91-9	CH₅NO₃S	详情	详情
(IX)	33370	(5-sulfanyl-1H-1,2,3,4-tetraazol-1-yl)methanesulfonic acid		C₂H₄N₄O₃S₂	详情	详情
(XIII)	33374	[[(methylsulfanyl)carbothioyl]amino]methanesulfonic acid		C₃H₇NO₃S₃	详情	详情

Extended Information