(1R,2S,4R,5S)-9-ethyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate -Drug Synthesis Database

【结构式】

【分子编号】33313

【品名】(1R,2S,4R,5S)-9-ethyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate

【CA登记号】

【分子式】C₁₈H₂₃NO₄

【分子量】317.38496

【元素组成】C 68.12% H 7.3% N 4.41% O 20.16%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Compound can be prepared in three steps starting from (-)-scopalamine (hyoscine) (I) by demethylation of (-)-scopolamine with phosgene or potassium permanganate, by alkylation of the resulting (-)-norscopolamine (II) with ethylbromide (A) by means of sodium carbonate, and by quaternization of the resulting (-)-N-ethyl-norscopolamine (III) with methylbromide yielding Ba-253-BR.

参考文献中间体

合成目标

【1】 Dharma, A.P.; Oxitropium bromide. Drugs Fut 1979, 4, 2, 117.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	30344	1-bromoethane；ethyl bromide	74-96-4	C₂H₅Br	详情	详情
(I)	33311	(1R,2S,4R,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate		C₁₇H₂₁NO₄	详情	详情
(II)	33312	(1R,2S,4R,5S)-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate		C₁₆H₁₉NO₄	详情	详情
(III)	33313	(1R,2S,4R,5S)-9-ethyl-3-oxa-9-azatricyclo[3.3.1.0(2,4)]non-7-yl (2S)-3-hydroxy-2-phenylpropanoate		C₁₈H₂₃NO₄	详情	详情

Extended Information