• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】33308

【品名】1-[benzyl(chlorocarbonyl)amino]-4-(1-cyanopropyl)benzene

【CA登记号】

【 分 子 式 】C18H17ClN2O

【 分 子 量 】312.79856

【元素组成】C 69.12% H 5.48% Cl 11.33% N 8.96% O 5.11%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVII)

The reaction of benzaldehyde (VI) with p-amino-alpha-ethylphenylacetonitrile (XIV) in refluxing toluene gives p-benzylideneamino-alpha-ethylphenylacetonitrile (XV), which is reduced with H2 over PtO2 in ethanol yielding p-benzylamino-alpha-ethylphenylacetonitrile (XVI). The acylation of (XVI) with phosgene by means of pyridine in toluene affords the N-chlorocarbo-nyl compound (XVII), which is cyclized with AlCl3 in refluxing 1,2-dichloroethane to yield 1-oxo-2-[p-(alpha-ethyl-cyanomethyl)phenyl]isoindoline (XVIII). Finally, this compound is hydrolyzed with H2SO4 in refluxing water.

1 Giraldi, P.N.; et al.; Verfahren zur Herstellung von Isoindolinderivaten. AT 325604B; CA 994785; CH 581106; JP 48057965; NL 7215830 .
2 de Angelis, L.; Castaner, J.; Indobufen. Drugs Fut 1979, 4, 2, 109.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(VI) 10498 Benzaldehyde;Benzoic aldehyde;Phenylmethanal 100-52-7 C7H6O 详情 详情
(XIV) 33305 2-(4-aminophenyl)butanenitrile C10H12N2 详情 详情
(XV) 33306 2-(4-[[(E)-benzylidene]amino]phenyl)butanenitrile C17H16N2 详情 详情
(XVI) 33307 2-[4-(benzylamino)phenyl]butanenitrile C17H18N2 详情 详情
(XVII) 33308 1-[benzyl(chlorocarbonyl)amino]-4-(1-cyanopropyl)benzene C18H17ClN2O 详情 详情
(XVIII) 33309 2-[4-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)phenyl]butanenitrile C18H16N2O 详情 详情
Extended Information