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【结 构 式】 
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【分子编号】33294 【品名】1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-imidazole; 3-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)propyl 2,6-dichlorophenyl sulfide 【CA登记号】 |
【 分 子 式 】C19H17Cl3N2S 【 分 子 量 】411.78156 【元素组成】C 55.42% H 4.16% Cl 25.83% N 6.8% S 7.79% |
合成路线1
该中间体在本合成路线中的序号：(V)The chlorohydrin (II) is obtained by the reaction of p-chlorobenzylmagnesium chloride (I) with epichlorohydrin (A) in ether. This is then converted to the crystalline alcohol (III) by reaction with sodium imidazole (B) in DMF. On treatment with thionyl chloride is converted to the corresponding chloro compound (IV). When (IV) is reacted with 2,6-dichloro thiophenol (C) in the presence of anhydrous potassium carbonate in acetone, the free base of butoconazole is formed. Neutralization of the free base (V) with nitric acid gives butoconazole.
| 【1】 Walker, K.A.M.; et al.; 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenylthio)n-butil]-1H-imidazole nitrate, a new patent antifungal agent. J Med Chem 1978, 21, 8, 840. |
| 【2】 Arya, V.P.; Butoconazole nitrate. Drugs Fut 1979, 4, 2, 89. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (A) | 10146 | Epichlorohydrin; 2-(Chloromethyl)oxirane | 106-89-8 | C3H5ClO | 详情 | 详情 |
| (B) | 10255 | Imidazole; 1H-Imidazole | 288-32-4 | C3H4N2 | 详情 | 详情 |
| (I) | 33290 | Bromo(4-chlorobenzyl)magnesium; p-Chlorobenzylmagnesium chloride | C7H6BrClMg | 详情 | 详情 | |
| (II) | 33291 | 1-chloro-4-(4-chlorophenyl)-2-butanol | C10H12Cl2O | 详情 | 详情 | |
| (III) | 16486 | 4-(4-chlorophenyl)-1-(1H-imidazol-1-yl)-2-butanol | C13H15ClN2O | 详情 | 详情 | |
| (IV) | 33292 | 1-[2-chloro-4-(4-chlorophenyl)butyl]-1H-imidazole | C13H14Cl2N2 | 详情 | 详情 | |
| (V) | 33294 | 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl]-1H-imidazole; 3-(4-chlorophenyl)-1-(1H-imidazol-1-ylmethyl)propyl 2,6-dichlorophenyl sulfide | C19H17Cl3N2S | 详情 | 详情 | |
| (C) | 33293 | 2,6-Dichloro thiophenol; 2,6-Dichlorobenzenethiol; 2,6-Dichlorophenylhydrosulfide | 24966-39-0 | C6H4Cl2S | 详情 | 详情 |