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【结 构 式】 
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【分子编号】33279 【品名】1-(2-methyl-5-nitro-1H-imidazol-1-yl)acetone 【CA登记号】 |
【 分 子 式 】C7H9N3O3 【 分 子 量 】183.16688 【元素组成】C 45.9% H 4.95% N 22.94% O 26.2% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VII)The reaction of (I) with chloroacetone (C) by means of K2CO3 in refluxing acetone gives (2-methylimidazol-1-yl)acetone (VI), which is nitrated with HNO3 and P2O5 affording the corresponding nitro compound (VII). Finally, this product is reduced with NaBH4 in methanol at room temperature.
| 【1】 Cosar, C.; Crisan, C.; Horclois, R.; Jacob, R.M.; Robert, J.; Tchelitcheff, S.; Vaupre,R.; Nitroimidazoles. Arzneim-Forsch Drug Res 1966, 16, 1, 23-29. |
| 【2】 Jeanmart, C.; Messer, M. (Aventis Pharma SA); Process for the preparation of 5-nitroimidazole derivatives. CH 513177; DE 2107423; FR 2079879; GB 1278758; NL 7101641 . |
| 【3】 Hillier, K.; Secnidazole. Drugs Fut 1979, 4, 4, 280. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15670 | 2-Methylimidazole; 2-Methyl-1H-imidazole | 693-98-1 | C4H6N2 | 详情 | 详情 |
| (VI) | 33278 | (2-methylimidazol-1-yl)acetone; 1-(2-methyl-1H-imidazol-1-yl)acetone | C7H10N2O | 详情 | 详情 | |
| (VII) | 33279 | 1-(2-methyl-5-nitro-1H-imidazol-1-yl)acetone | C7H9N3O3 | 详情 | 详情 | |
| (C) | 15288 | 1-Chloroacetone; Chloroacetone | 78-95-5 | C3H5ClO | 详情 | 详情 |
Extended Information