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【结 构 式】 
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【分子编号】33256 【品名】3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-chloronicotinate 【CA登记号】 |
【 分 子 式 】C14H8ClNO4 【 分 子 量 】289.67456 【元素组成】C 58.05% H 2.78% Cl 12.24% N 4.84% O 22.09% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Two different ways to obtain talniflumate were developed: The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I). The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV), which is then treated with 3-trifluoromethylaniline (V).
| 【1】 Boned, J.; Los, M.; Piccinali, C.; Acidos anilino nicotinico y N-arilantranilicos convenientemente sustituidos. VII Latinoamerican Congress Pharmacology 1978. |
| 【2】 GB 381578 . |
| 【3】 US 879749 . |
| 【4】 Procedimiento para la obtencion de nuevos esterees de acidos fenil- y piridin-3-carboxilicos sustituidos. ES 474566 . |
| 【5】 Phthalidyl 2-(3'-trifluoromethylanilino)pyridine-3-caboxylalate and process for its preparation. AR 209858; GB 1553171 . |
| 【6】 Nouveaux esters d'acides phényl- et pyridine-3-carboxylique et procédé premettant leur préparation. BE 0858864 . |
| 【7】 Torriani, H.; Talniflumate. Drugs Fut 1979, 4, 6, 448. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 24560 | 3-Bromophthalide; 3-Bromo-2-benzofuran-1(3H)-one | 6940-49-4 | C8H5BrO2 | 详情 | 详情 |
| (II) | 33257 | sodium 2-[3-(trifluoromethyl)anilino]nicotinate | C13H8F3N2NaO2 | 详情 | 详情 | |
| (III) | 33255 | sodium 2-chloronicotinate | C6H3ClNNaO2 | 详情 | 详情 | |
| (IV) | 33256 | 3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-chloronicotinate | C14H8ClNO4 | 详情 | 详情 | |
| (V) | 26347 | 3-(trifluoromethyl)phenylamine; 3-(trifluoromethyl)aniline; 3-aminobenzotrifluoride | 98-16-8 | C7H6F3N | 详情 | 详情 |
Extended Information