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【结 构 式】

【分子编号】33256

【品名】3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-chloronicotinate

【CA登记号】

【 分 子 式 】C14H8ClNO4

【 分 子 量 】289.67456

【元素组成】C 58.05% H 2.78% Cl 12.24% N 4.84% O 22.09%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Two different ways to obtain talniflumate were developed: The first method is by reacting the previously salified niflumic acid (II) with 3-bromophthalide (I). The second way is by condensation of salified 2-halonicotinic acid (III) with 3-bromophthalide (I) to give the corresponding phthalidyl ester (IV), which is then treated with 3-trifluoromethylaniline (V).

1 Boned, J.; Los, M.; Piccinali, C.; Acidos anilino nicotinico y N-arilantranilicos convenientemente sustituidos. VII Latinoamerican Congress Pharmacology 1978.
2 GB 381578 .
3 US 879749 .
4 Procedimiento para la obtencion de nuevos esterees de acidos fenil- y piridin-3-carboxilicos sustituidos. ES 474566 .
5 Phthalidyl 2-(3'-trifluoromethylanilino)pyridine-3-caboxylalate and process for its preparation. AR 209858; GB 1553171 .
6 Nouveaux esters d'acides phényl- et pyridine-3-carboxylique et procédé premettant leur préparation. BE 0858864 .
7 Torriani, H.; Talniflumate. Drugs Fut 1979, 4, 6, 448.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 24560 3-Bromophthalide; 3-Bromo-2-benzofuran-1(3H)-one 6940-49-4 C8H5BrO2 详情 详情
(II) 33257 sodium 2-[3-(trifluoromethyl)anilino]nicotinate C13H8F3N2NaO2 详情 详情
(III) 33255 sodium 2-chloronicotinate C6H3ClNNaO2 详情 详情
(IV) 33256 3-oxo-1,3-dihydro-2-benzofuran-1-yl 2-chloronicotinate C14H8ClNO4 详情 详情
(V) 26347 3-(trifluoromethyl)phenylamine; 3-(trifluoromethyl)aniline; 3-aminobenzotrifluoride 98-16-8 C7H6F3N 详情 详情
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