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【结 构 式】

【分子编号】32955

【品名】3-ethoxybenzoyl chloride

【CA登记号】61956-65-8

【 分 子 式 】C9H9ClO2

【 分 子 量 】184.62196

【元素组成】C 58.55% H 4.91% Cl 19.2% O 17.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Reduction of ethyl 4-piperidinecarboxylate (I) with LiAlH4 in THF provided 4-piperidinemethanol (II), which was coupled with 3-ethoxybenzoyl chloride (III) in the presence of Et3N, yielding amide (IV). Subsequent treatment of (IV) with p-toluenesulfonyl chloride in pyridine afforded the corresponding tosylate (V. This was finally condensed with 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline (VI) to furnish the title compound.

1 George, P.; Sevrin, M.; Maloizel, C.; Tixidre, A.; Froissant, J. (Sanofi-Synthelabo ); Derivs. of 2-[(4-piperidinyl)methyl]-1,2,3, 4-tetrahydroisoquinoline, their use in therapy. AU 8929617; EP 0351255; JP 1990025481; US 4925850 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 17410 Ethyl isonipecotate; ethyl 4-piperidinecarboxylate 1126-09-6 C8H15NO2 详情 详情
(II) 32954 4-piperidinylmethanol C6H13NO 详情 详情
(III) 32955 3-ethoxybenzoyl chloride 61956-65-8 C9H9ClO2 详情 详情
(IV) 32956 (3-ethoxyphenyl)[4-(hydroxymethyl)-1-piperidinyl]methanone C15H21NO3 详情 详情
(V) 32957 [1-(3-ethoxybenzoyl)-4-piperidinyl]methyl 4-methylbenzenesulfonate C22H27NO5S 详情 详情
(VI) 32958 5,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline; 5-methoxy-1,2,3,4-tetrahydro-8-isoquinolinyl methyl ether C11H15NO2 详情 详情
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