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【结 构 式】 
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【分子编号】32840 【品名】2-(4-bromo-3-methylphenyl)-5-methyl-1,3,4-oxadiazole 【CA登记号】 |
【 分 子 式 】C10H9BrN2O 【 分 子 量 】253.09834 【元素组成】C 47.46% H 3.58% Br 31.57% N 11.07% O 6.32% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)Palladium-catalyzed coupling of phenyloxadiazol derivative (VIII) with 4-boronobenzoic acid (IX) yielded biphenyl (X). Further treatment of (X) with SOCl2 afforded acid chloride (XI). This was finally condensed with amine (VII) to provide the title carboxamide.
| 【1】 Gaster, L.M.; King, F.D.; Wyman, P.A. (GlaxoSmithKline plc); Tetracyclic spiro cpds., process for their preparation and their use as 5HT1D receptor antagonists. EP 0799226; JP 1998510821; US 5972951; WO 9619477 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (VII) | 32844 | 1'-Ethyl-3,5,6,7-tetrahydro-2H-spiro[furo[2,3-f]indole-3,4'-piperidine] | C16H22N2O | 详情 | 详情 | |
| (VIII) | 32840 | 2-(4-bromo-3-methylphenyl)-5-methyl-1,3,4-oxadiazole | C10H9BrN2O | 详情 | 详情 | |
| (IX) | 32841 | 4-(dihydroxyboryl)benzoic acid；4-Boronobenzoic acid；4-carboxyphenylboronic acid;4-(Dihydroxyboryl)benzoic acid | 14047-29-1 | C7H7BO4 | 详情 | 详情 |
| (X) | 32842 | 2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)[1,1'-biphenyl]-4-carboxylic acid | C17H14N2O3 | 详情 | 详情 | |
| (XII) | 32843 | 2'-methyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)[1,1'-biphenyl]-4-carbonyl chloride | C17H13ClN2O2 | 详情 | 详情 |
Extended Information