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【结 构 式】 
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【分子编号】32793 【品名】methyl (2S)-2-[[(4-bromophenoxy)(chloro)phosphoryl]amino]propanoate 【CA登记号】 |
【 分 子 式 】C10H12BrClNO4P 【 分 子 量 】356.540082 【元素组成】C 33.69% H 3.39% Br 22.41% Cl 9.94% N 3.93% O 17.95% P 8.69% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The intermediate phosphorochloridate (III) has been obtained as follows: The reaction of 4-bromophenol (IV) with POCl3 and triethylamine in ethyl ether gives the corresponding phosphorodichloridate (V), which is finally condensed with L-alanine methyl ester (VI) by means of triethylamine in dichloromethane.
| 【1】 Uckun, F.M. (Parker Hughes Institute); Aryl phosphate derivatives of d4T having anti-HIV activity. WO 0000501 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 32793 | methyl (2S)-2-[[(4-bromophenoxy)(chloro)phosphoryl]amino]propanoate | C10H12BrClNO4P | 详情 | 详情 | |
| (IV) | 25313 | 4-bromophenol | 106-41-2 | C6H5BrO | 详情 | 详情 |
| (V) | 25314 | Dichlorophoephoric acid 4-bromophenyl ester | C6H4BrCl2O2P | 详情 | 详情 | |
| (VI) | 20694 | methyl (2S)-2-aminopropanoate | C4H9NO2 | 详情 | 详情 |
Extended Information