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【结 构 式】

【分子编号】32772

【品名】(2S)-1-[(2-nitroanilino)carbonyl]-2-pyrrolidinecarboxylic acid

【CA登记号】

【 分 子 式 】C12H13N3O5

【 分 子 量 】279.25244

【元素组成】C 51.61% H 4.69% N 15.05% O 28.65%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The reaction of N-(tert-butoxycarbonyl)-L-(2-naphthyl)alanine (I) with N-methylbenzyamine (II) by means of isobutyl chloroformate and NMM in dichloromethane gives the corresponding amide (III), which is deprotected with HCl in dioxane yielding (IV) with a free amino group. Finally, this compound is condensed with 1-[N-(2-nitrophenyl)carbamoyl]-L-proline (V) by means of HOBT and DCC in THF. The intermediate 1-[N-(2-nitrophenyl)carbamoyl]-L-proline (V) has been obtained by reaction of L-proline (VI) with 2-nitrophenyl isocyanate (VII) by means of NMM in THF/water.

1 Prashad, M.; et al.; Process development of (2-nitrophenylcarbamoyl)-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide (SDZ NKT343). Org Process Res Dev 1999, 3, 6, 409.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 15061 (2S)-2-[(tert-butoxycarbonyl)amino]-3-(2-naphthyl)propionic acid; N-T-BOC-L-3-(2-NAPHTHYL)ALANINE 58438-04-3 C18H21NO4 详情 详情
(II) 11969 N-Methyl(phenyl)methanamine; N-Benzyl-N-methylamine; N-Methylbenzylamine 103-67-3 C8H11N 详情 详情
(III) 15062 tert-butyl N-[(1S)-2-[benzyl(methyl)amino]-1-(2-naphthylmethyl)-2-oxoethyl]carbamate C26H30N2O3 详情 详情
(IV) 15063 (2S)-2-amino-N-benzyl-N-methyl-3-(2-naphthyl)propanamide C21H22N2O 详情 详情
(V) 32772 (2S)-1-[(2-nitroanilino)carbonyl]-2-pyrrolidinecarboxylic acid C12H13N3O5 详情 详情
(VI) 16731 L-proline 147-85-3 C5H9NO2 详情 详情
(VII) 32771 1-isocyanato-2-nitrobenzene; 2-nitrophenyl isocyanate 3320-86-3 C7H4N2O3 详情 详情
Extended Information