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【结 构 式】 
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【分子编号】32733 【品名】sodium 1,2-benzisoxazol-3-ylmethanesulfonate 【CA登记号】 |
【 分 子 式 】C8H6NNaO4S 【 分 子 量 】235.195748 【元素组成】C 40.85% H 2.57% N 5.96% Na 9.77% O 27.21% S 13.63% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)The reaction of 3-bromomethyl-1,2-benzisoxazole (I) with sodium sulfite in hot methanol - water gives sodium 1,2-benzisoxazole-3-methanesulfonate (II), which by reaction with refluxing POCl3 is converted into 1,2-benzisoxazole-3-methanesufonyl chloride (III). Finally, this compound is treated with dry NH3 in ethyl acetate.
| 【1】 Uno, H.; et al. (Dainippon Pharmaceutical Co., Ltd.); Methane-sulfonamide derivatives, the preparation thereof and composition comprising the same. US 4172896 . |
| 【2】 Castaner, J.; Owen, R.T.; Blancafort, P.; Serradell, M.N.; AD-810. Drugs Fut 1980, 5, 8, 387. |
合成路线2
该中间体在本合成路线中的序号：(II)
| 【1】 Naddaka V, Adin I .Klopfer E, et al. 2006. Two crystalline forms of sodium l,2-benzisoxazole-3-methanesulfonate, and processes for the preparation and use thereof in the synthesis of zonisarrude. US 20Q6009644 |
Extended Information