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【结 构 式】 
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【分子编号】32710 【品名】docosanoic anhydride 【CA登记号】55726-23-3 |
【 分 子 式 】C44H86O3 【 分 子 量 】663.16504 【元素组成】C 79.69% H 13.07% O 7.24% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)This compound can be obtained in two different ways: 1) By condensation of 1-beta-D-arabinofuranosylcytosine (I) with docosanoyl anhydride (II) in hot dioxane. 2) By acylation of cytidine (III) with docosanoyl anhydride (II) as before to give N4-docosanoylcytidine (IV), which is then isomerized by treatment with POCl3 in ethyl acetate.
| 【1】 Akiyama, M.; et al.; The synthesis of new derivatives of 1-beta-D-arabinofuranosylcytosine. Chem Pharm Bull 1978, 26, 3, 981-984. |
| 【2】 Ishida, T.; et al.; JP 7626884 . |
| 【3】 Ishida, T.; et al.; JP 7648679 . |
| 【4】 Ishida, T.; et al.; JP 7632573 . |
| 【5】 Ishida, T.; et al.; N4-Acylarabinonucleosides apparatus for handling articles. DE 2461862; FR 2342070; JP 51019777 . |
| 【6】 Ishida, T.; et al.; N4-Acylarabinonucleosides and the preparation thereof. DE 426304; FR 2231388; GB 1449708; JP 50018482 . |
| 【7】 Serradell, M.N.; Cabanillas, F.; Castaner, J.; Blancafort, P.; Behenoyl Ara-C. Drugs Fut 1980, 5, 12, 603. |
| 【8】 Ishida, T.; et al. (Asahi Chemical Industry Co., Ltd.); Process for preparing N4-acylcytarabines. JP 52007974 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 32709 | Cytarabine; Cytosine Beta-D-Arabinofuranoside; 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone | 147-94-4 | C9H13N3O5 | 详情 | 详情 |
| (II) | 32710 | docosanoic anhydride | 55726-23-3 | C44H86O3 | 详情 | 详情 |
| (III) | 27920 | Cytidine; 4-amino-1-((2S,3S,4S,5S)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one;4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2(1H)-pyrimidinone | 65-46-3 | C9H13N3O5 | 详情 | 详情 |
| (IV) | 31711 | 1-(2-diazo-1-phenylethyl)benzene | C14H12N2 | 详情 | 详情 |
Extended Information