【结 构 式】 |
【分子编号】32591 【品名】methyl 3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoate 【CA登记号】 |
【 分 子 式 】C15H20Cl2N2O4 【 分 子 量 】363.24028 【元素组成】C 49.6% H 5.55% Cl 19.52% N 7.71% O 17.62% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(III)Mitsunobu coupling of 2-(4-methylpiperazin-1-yl)ethanol (I) with 3,5-dichloro-2,4-dihydroxybenzoic acid (II) in the presence of diisopropyl azodicarboxylate and triphenylphosphine afforded ether (III). Subsequent hydrolysis of the methyl ester group of (III) provided acid (IV), which was coupled with L-phenylalanine methyl ester-HCl (V) employing EDC and HOBt. The title compound was finally isolated as the corresponding dihydrochloride salt.
【1】 Haruta, J.; Sakuma, K.; Watanabe, Y. (Japan Tobacco Inc.); Amide compounds and use of the same. EP 0849256 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 32589 | 2-(4-methyl-1-piperazinyl)-1-ethanol | 5464-12-0 | C7H16N2O | 详情 | 详情 |
(II) | 32590 | methyl 3,5-dichloro-2,4-dihydroxybenzoate | C8H6Cl2O4 | 详情 | 详情 | |
(III) | 32591 | methyl 3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoate | C15H20Cl2N2O4 | 详情 | 详情 | |
(IV) | 32592 | 3,5-dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoic acid | C14H18Cl2N2O4 | 详情 | 详情 | |
(V) | 32593 | ethyl (2S)-2-amino-3-phenylpropanoate | C11H15NO2 | 详情 | 详情 |
Extended Information