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【结 构 式】 
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【分子编号】32284 【品名】ethyl 2-amino-3-[4-chloro-2-(2-fluorobenzoyl)anilino]-3-oxopropanoate 【CA登记号】 |
【 分 子 式 】C18H16ClFN2O4 【 分 子 量 】378.7872232 【元素组成】C 57.08% H 4.26% Cl 9.36% F 5.02% N 7.4% O 16.9% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)2-Amino-5-chloro-2'-fluorobenzophenone (I) is condensed with monoethyl methoxycarbonyl aminomalonate (II) and the crude product obtained (III) is deprotected by HBr to give the free amine hydrobromide (IV). This product is then cyclized in a mixture of acetic acid-sodium acetate to obtain CM-6912, which is separated by filtration and recrystallized in ethanol.
| 【1】 Demarne, H.; Hallot, A.; Benzodiazepine derivatives and pharmaceutical compositions thereof. DE 2719608; FR 2350346; GB 1538164; JP 57081472; NL 7704911; NL 7704912; US 4235897 . |
| 【2】 Dubois, M.; Ethyl Loflazepate. Drugs Fut 1981, 6, 12, 772. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 32281 | 2-Amino-5-chloro-2'-fluorobenzophenone; (2-Amino-5-chlorophenyl)(2-fluorophenyl)methanone | 784-38-3 | C13H9ClFNO | 详情 | 详情 |
| (II) | 32282 | 3-ethoxy-N-(methoxycarbonyl)-3-oxoalanine | C7H11NO6 | 详情 | 详情 | |
| (III) | 32283 | ethyl 3-[4-chloro-2-(2-fluorobenzoyl)anilino]-2-[(methoxycarbonyl)amino]-3-oxopropanoate | C20H18ClFN2O6 | 详情 | 详情 | |
| (IV) | 32284 | ethyl 2-amino-3-[4-chloro-2-(2-fluorobenzoyl)anilino]-3-oxopropanoate | C18H16ClFN2O4 | 详情 | 详情 |
Extended Information