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【结 构 式】 
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【分子编号】32231 【品名】1-(3-hydroxypropyl)-2,6-cis-dimethylpiperidine; 3-[(2R,6S)-2,6-dimethylpiperidinyl]-1-propanol 【CA登记号】 |
【 分 子 式 】C10H21NO 【 分 子 量 】171.28288 【元素组成】C 70.12% H 12.36% N 8.18% O 9.34% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(VIII)The reaction of dimethylpiperidine (IV) with 3-bromopropanol (VII) in refluxing xylene gives 1-(3-hydroxypropyl)-2,6-cis-dimethylpiperidine (VIII), which by treatment with SOCl2 in refluxing benzene is converted into 1-(3-chloropropyl)-2,6-cis-dimethylpiperidine (IX). Finally, this compound is condensed with 2-benzoylpyridine (X) by means of Li in THF.
| 【1】 Fleming, R.W. (Pfizer Inc.); Antiarrhythmic (+,-)-cis- alpha [3-(2,6-dimethyl-1-piperidinyl)propyl]-alpha-phenyl-2-pyridinemethanols. US 4112103 . |
| 【2】 Blancafort, P.; Serradell, M.N.; Castaner, J.; Hillier, K.; Pirmenol hydrochloride. Drugs Fut 1981, 6, 4, 234. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IV) | 32229 | (2R,6S)-2,6-dimethylpiperidine; cis-2,6-dimethylpiperidine | C7H15N | 详情 | 详情 | |
| (VII) | 12573 | 3-Bromo-1-propanol; 3-Bromopropanol | 627-18-9 | C3H7BrO | 详情 | 详情 |
| (VIII) | 32231 | 1-(3-hydroxypropyl)-2,6-cis-dimethylpiperidine; 3-[(2R,6S)-2,6-dimethylpiperidinyl]-1-propanol | C10H21NO | 详情 | 详情 | |
| (IX) | 32232 | 1-(3-chloropropyl)-2,6-cis-dimethylpiperidine; (2R,6S)-1-(3-chloropropyl)-2,6-dimethylpiperidine | C10H20ClN | 详情 | 详情 | |
| (X) | 32233 | 2-Benzoylpyridine; Phenyl(2-pyridinyl)methanone | 91-02-1 | C12H9NO | 详情 | 详情 |
Extended Information