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【结 构 式】

【分子编号】32219

【品名】1-(2-chloroethyl)-4-ethyl-1,4-dihydro-5H-1,2,3,4-tetraazol-5-one

【CA登记号】

【 分 子 式 】C5H9ClN4O

【 分 子 量 】176.60552

【元素组成】C 34.01% H 5.14% Cl 20.07% N 31.72% O 9.06%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

The cyclization of ethyl isocyanate (I) with sodium azide (II) by means of AlCl3 in refluxing THF gives 1-ethyl-1,4-dihydro-5H-tetrazol-5-one (III), which is alkylated with 1-chloro-2-bromoethane (IV) by means of Na2CO3 and KI in refluxing 4-methyl-2-pentanone to afford 1-ethyl-4-(2-chloroethyl)-1,4-dihydro-5H-tetrazol-5-one (V). Finally, this compound is condensed with N-(4-methoxymethyl-4-piperidinyl)propionanilide (VI) by means of Na2CO4 - KI in refluxing 4-methyl-2-pentanone.

1 Janssen, F. (Janssen Pharmaceutica NV); N-Phenyl-N-(4-piperidinyl)amides. DE 2819873; ES 469473; FR 2389622; GB 1598872; JP 53149980 .
2 Castaner, J.; Leeson, P.A.; Blancafort, P.; Mealy, N.E.; Serradell, M.N.; Alfentanil hydrochloride. Drugs Fut 1981, 6, 6, 335.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28738 ethyl isocyanate 109-90-0 C3H5NO 详情 详情
(III) 32218 1-ethyl-1,4-dihydro-5H-1,2,3,4-tetraazol-5-one 69048-98-2 C3H6N4O 详情 详情
(IV) 24271 1-bromo-2-chloroethane 107-04-0 C2H4BrCl 详情 详情
(V) 32219 1-(2-chloroethyl)-4-ethyl-1,4-dihydro-5H-1,2,3,4-tetraazol-5-one C5H9ClN4O 详情 详情
(VI) 32220 N-[4-(methoxymethyl)-4-piperidinyl]-N-phenylpropanamide C16H24N2O2 详情 详情
Extended Information