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【结 构 式】

【分子编号】32214

【品名】methyl 6-methoxy-1H-1,2,3-benzotriazole-5-carboxylate

【CA登记号】

【 分 子 式 】C9H9N3O3

【 分 子 量 】207.18888

【元素组成】C 52.17% H 4.38% N 20.28% O 23.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The nitration of methyl 2-methoxy-4-aminobenzoate (I) with nitric acid in acetic acid-acetic anhydride, followed by hydrolysis with methanolic H2SO4 gives methyl 2-methoxy-4-amino-5-nitrobenzoate (II), which is reduced with H2 over Raney-Ni in methanol to yield methyl-2-methoxy-4,5-diaminohenzoate (III). The cyclization of (III) with NaNO2 in aqueous HCl affords methyl 6-methoxybenzotriazole-5-carboxylate (IV), which is finally condensed with 1-allylpyrrolidin-2-ylmethylamine (V) in refluxing toluene.

1 Leeson, P.A.; Serradell, M.N.; Castaner, J.; Blancafort, P.; Mealy, N.E.; Alizapride. Drugs Fut 1981, 6, 1, 11.
2 Bulteau, G.; Acher, J.; Collignon, C.; Monier, J.-C. (Societe d'Etudes Scientifiques et Industrielles de L'Ile de France); N-(1'-allypyrrolidinyl-2'-methyl)-2-methoxy-4,5-azimido benzamide and its pharmaceutically acceptable salts. US 4039672 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 12416 methyl 4-amino-2-methoxybenzoate 27492-84-8 C9H11NO3 详情 详情
(II) 32212 methyl 4-amino-2-methoxy-5-nitrobenzoate C9H10N2O5 详情 详情
(III) 32213 methyl 4,5-diamino-2-methoxybenzoate C9H12N2O3 详情 详情
(IV) 32214 methyl 6-methoxy-1H-1,2,3-benzotriazole-5-carboxylate C9H9N3O3 详情 详情
(V) 32211 (1-allyl-2-pyrrolidinyl)methanamine; (1-allyl-2-pyrrolidinyl)methylamine 66411-51-6 C8H16N2 详情 详情
Extended Information