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【结 构 式】 
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【分子编号】32163 【品名】Dibromomethane 【CA登记号】74-95-3 |
【 分 子 式 】CH2Br2 【 分 子 量 】173.83488 【元素组成】C 6.91% H 1.16% Br 91.93% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The reaction of dibromomethane (I) with triisopropylphosphite (II) at 145 C gives tetraisopropyl methylenediphosphonate (III), which is treated first with sodium and then with chlorine to give the compound (IV). This compound is finally hydrolyzed with refluxing concentrated HCl, or treated with refluxing tetrachloroethane.
| 【1】 Nicholson, D.A.; Prentice, J.B.; Quimby, O.T.; Tetrasodium carbonyldiphosphonate. Synthesis reactions and spectral properties. J Org Chem 1967, 32, 12, 4111-14. |
| 【2】 Roy, C.H.; Substituted methylene diphosphonic acids and their salts. NL 6514133 . |
| 【3】 Roy, C.H. (The Procter & Gamble Co.); Substituted methylene diphosphonic acids and their salts. BE 0672205; DE 1793768; FR 1457272; GB 1026366; US 3404178; US 3422021 . |
| 【4】 Castaner, J.; Hopkins, S.J.; Blancafort, P.; Serradell, M.N.; Clodronate disodium. Drugs Fut 1982, 7, 9, 615. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 32163 | Dibromomethane | 74-95-3 | CH2Br2 | 详情 | 详情 |
| (II) | 32162 | Triisopropyl phosphite | 116-17-6 | C9H21O3P | 详情 | 详情 |
| (III) | 27980 | Diisopropyl (diisopropoxyphosphoryl)methylphosphonate; Tetraisopropyl methylenediphosphonate | 1660-95-3 | C13H30O6P2 | 详情 | 详情 |
| (IV) | 32164 | diisopropyl dichloro(diisopropoxyphosphoryl)methylphosphonate | C13H28Cl2O6P2 | 详情 | 详情 |
Extended Information