2-methyl-4-(2-oxiranylmethoxy)-1(2H)-isoquinolinone -Drug Synthesis Database

【结构式】

【分子编号】32095

【品名】2-methyl-4-(2-oxiranylmethoxy)-1(2H)-isoquinolinone

【CA登记号】

【分子式】C₁₃H₁₃NO₃

【分子量】231.25116

【元素组成】C 67.52% H 5.67% N 6.06% O 20.76%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

The condensation of N-methyl-4-hydroxyisocarbostyril (I) with epichlorohydrin (II) by means of sodium methoxide in hot methanol gives 4-(2,3-epoxypropoxy)-N-methylisocarbostyril (III), which is then treated with tert-butylamine (IV) in methanol, and with HCl.

参考文献中间体

合成目标

【1】 Fukushima, H.; Suzuki, Y. (Nisshin Flour Milling Co., Ltd.); Isocarbostyril derivatives. DE 2631080; GB 1501149; JP 52012178 .
【2】 Serradell, M.N.; Blancafort, P.; Thorpe, P.J.; Castaner, J.; N-696. Drugs Fut 1982, 7, 12, 889.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
	17895	2-Amino-2-methylpropane; tert-butylamine; 2-methyl-2-propanamine	75-64-9	C₄H₁₁N	详情	详情
(I)	32094	4-hydroxy-2-methyl-1(2H)-isoquinolinone		C₁₀H₉NO₂	详情	详情
(II)	10146	Epichlorohydrin; 2-(Chloromethyl)oxirane	106-89-8	C₃H₅ClO	详情	详情
(III)	32095	2-methyl-4-(2-oxiranylmethoxy)-1(2H)-isoquinolinone		C₁₃H₁₃NO₃	详情	详情

Extended Information