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【结 构 式】 
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【分子编号】31956 【品名】Ethyl (2-hydroxypropyl)amine; 1-(Ethylamino)-2-propanol 【CA登记号】40171-86-6 |
【 分 子 式 】C5H13NO 【 分 子 量 】103.16436 【元素组成】C 58.21% H 12.7% N 13.58% O 15.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(A)This compound can be prepared by two related ways: 1) The reaction of ethyl (2-hydroxypropyl)amine (A) with 3,6-dichloropyridazine (I) in refluxing toluene gives 3-chloro-6-[ethyl(2-hydroxypropyl)amino]pyridazine (II). This intermediate is then reacted with ethyl hydrazinecarboxylate (B) to afford (III). 2) Alternatively, compound (II) may be treated with hydrazine hydrate to afford the hydrazinopyridazine (IV); acylation of (IV) with ethoxycarbonyl chloride provides the final compound (III).
| 【1】 Pifferi, G.; Parravicini, F.; Scarpitta, G.; Dorigotti, L.; Derivati della 3-idrazinopiridazina. Nota III. Sintesi ed attivita antiipertensiva di nuove 3-(2-acilidrazino)piridazine-6-alchilamino sostituite. Farm Sci Ed 1979, 34, 299-310. |
| 【2】 Citero, L.; Visconti, M.; Borsa, M.; Pifferi, G.; Analytical profile of cadralazine, a new antihypttensive agent. Boll Chim Farm 1981, 120, 222-233. |
| 【3】 Carpi, C.; Dorigotti, L.; Pifferi, G. (ISF SpA); 6-Substituted 3-carbethoxyhydrazinopyridazines. US 4002753 . |
| 【4】 Meran, C.; Cadralazine. Drugs Fut 1982, 7, 6, 382. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 27366 | Ethyl hydrazinecarboxylate; Ethyl 1-hydrazinecarboxylate | 4114-31-2 | C3H8N2O2 | 详情 | 详情 |
| (A) | 31956 | Ethyl (2-hydroxypropyl)amine; 1-(Ethylamino)-2-propanol | 40171-86-6 | C5H13NO | 详情 | 详情 |
| (I) | 11292 | 3,6-Dichloropyridazine | 141-30-0 | C4H2Cl2N2 | 详情 | 详情 |
| (II) | 31957 | 3-Chloro-6-[ethyl(2-hydroxypropyl)amino]pyridazine; 1-[(6-Chloro-3-pyridazinyl)(ethyl)amino]-2-propanol | 64241-33-4 | C9H14ClN3O | 详情 | 详情 |
| (III) | 31958 | ethyl 2-[6-[ethyl(2-hydroxypropyl)amino]-3-pyridazinyl]-1-hydrazinecarboxylate | C12H21N5O3 | 详情 | 详情 |
Extended Information