• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】31952

【品名】1H-imidazole-4,5-dicarbonyl dichloride

【CA登记号】

【 分 子 式 】C5H2Cl2N2O2

【 分 子 量 】192.98856

【元素组成】C 31.12% H 1.04% Cl 36.74% N 14.52% O 16.58%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(II)

The reaction of imidazole-4,5-dicarboxylic acid (I) with SOCl2 in refluxing benzene gives the corresponding acid chloride (II), which is condensed with 7-beta-[D-(-)-alpha-aminophenylacetamido]cephalosporanic acid sodium salt (III) by means of triethylamine in dichloromethane to afford 7-beta-[D-(-)-alpha-[4(5)-carboxyimidazole-5(4)-carboxamido]phenyl acetamidolcephalosporanic acid (IV). Finally, this compound is condensed with 4-pyridineethanesulfonic acid (V) by means of NaI in water at 70 C.

1 Yasuda, N.; Eguchi, C.; Okutsu, M.; Hirose, Y. (Ajinomoto Co., Inc.); Imidazoledicarboxylic acid substituted cephalosporin derivatives. DE 2826546; FR 2394550; JP 54005974; US 4217450 .
2 Castaner, J.; Serradell, M.N.; Blancafort, P.; AC-1370. Drugs Fut 1982, 7, 6, 373.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 31951 1H-imidazole-4,5-dicarboxylic acid 570-22-9 C5H4N2O4 详情 详情
(II) 31952 1H-imidazole-4,5-dicarbonyl dichloride C5H2Cl2N2O2 详情 详情
(III) 31953 Sodium (6R,7R)-3-[(acetoxy)methyl]-7-[[(2R)-2-amino-2-phenylethanoyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7- beta-[D-(-)-alpha-Aminophenylacetamido]cephalosporanic acid sodium salt C18H18N3NaO6S 详情 详情
(IV) 31954 7-beta-[D-(-)-alpha-[4(5)-Carboxyimidazole-5(4)-carboxamido]phenyl acetamidolcephalosporanic acid; Disodium (6R,7R)-3-[(acetoxy)methyl]-7-[((2R)-2-[[(4-carboxylato-1H-imidazol-5-yl)carbonyl]amino]-2-phenylethanoyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate C23H19N5Na2O9S 详情 详情
(V) 31955 4-Pyridineethanesulfonic acid; 2-(4-Pyridinyl)-1-ethanesulfonic acid 53054-76-5 C7H9NO3S 详情 详情
Extended Information