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【结 构 式】 
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【分子编号】31827 【品名】benzyl 2-[(3S,6R,9S,12S,15R,18S,21S,25S)-21-(3-amino-3-oxopropyl)-6,15,18-triisobutyl-12-isopropyl-3-[(1S)-1-methylpropyl]-25-(10-methylundecyl)-2,5,8,11,14,17,20,23-octaoxo-1-oxa-4,7,10,13,16,19,22-heptaazacyclopentacosan-9-yl]acetate 【CA登记号】 |
【 分 子 式 】C60H100N8O12 【 分 子 量 】1125.50072 【元素组成】C 64.03% H 8.96% N 9.96% O 17.06% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVIII)Then, liberation from the resin by means of Et3N-AcOH proceded with concomitant cyclization to form the cyclic depsipeptide (XVIII). The benzyl ester group was finally deprotected by hydrogenolysis in the presence of Pd/C.
| 【1】 Yanai, M.; Suguroi, T.; Solid-phase synthesis of cyclooctadepsipeptide N-4909 using a cyclization-cleavage method with oxime resin. J Antibiot 1999, 52, 9, 835. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XVII) | 31826 | (3S,6S,9R,12S,15S,18R,21S,24S)-24,27-diamino-12-[2-(benzyloxy)-2-oxoethyl]-9,18,21-triisobutyl-15-isopropyl-6-[(1S)-1-methylpropyl]-3-(10-methylundecyl)-5,8,11,14,17,20,23,27-octaoxo-4-oxa-7,10,13,16,19,22-hexaazaheptacosan-1-oic acid | C60H102N8O13 | 详情 | 详情 | |
| (XVIII) | 31827 | benzyl 2-[(3S,6R,9S,12S,15R,18S,21S,25S)-21-(3-amino-3-oxopropyl)-6,15,18-triisobutyl-12-isopropyl-3-[(1S)-1-methylpropyl]-25-(10-methylundecyl)-2,5,8,11,14,17,20,23-octaoxo-1-oxa-4,7,10,13,16,19,22-heptaazacyclopentacosan-9-yl]acetate | C60H100N8O12 | 详情 | 详情 |
Extended Information