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【结 构 式】

【分子编号】31825

【品名】(6S,9S,12R,15S,18S,21R,24S,27S)-6-(3-amino-3-oxopropyl)-18-[2-(benzyloxy)-2-oxoethyl]-9,12,21-triisobutyl-15-isopropyl-2,2-dimethyl-24-[(1S)-1-methylpropyl]-27-(10-methylundecyl)-4,7,10,13,16,19,22,25-octaoxo-3,26-dioxa-5,8,11,14,17,20,23-heptaazano

【CA登记号】

【 分 子 式 】C65H110N8O15

【 分 子 量 】1243.63332

【元素组成】C 62.78% H 8.92% N 9.01% O 19.3%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XVI)

The deprotection-coupling procedure was repeated using N-Boc-L-leucine (XIII), and N-Boc-L-glutamine (XV), yielding the depsipeptide resins (XII) and (XIV), respectively. Further cleavage of the Boc group provided the deprotected depsipeptide resin (XVII).

1 Yanai, M.; Suguroi, T.; Solid-phase synthesis of cyclooctadepsipeptide N-4909 using a cyclization-cleavage method with oxime resin. J Antibiot 1999, 52, 9, 835.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XII) 31823 (6S,9S,12S,15R,18S,21S)-12-[2-(benzyloxy)-2-oxoethyl]-6,15-diisobutyl-9-isopropyl-2,2-dimethyl-18-[(1S)-1-methylpropyl]-21-(10-methylundecyl)-4,7,10,13,16,19-hexaoxo-3,20-dioxa-5,8,11,14,17-pentaazatricosan-23-oic acid C54H91N5O12 详情 详情
(XIII) 31818 N-(tert-butoxycarbonyl)leucine C11H21NO4 详情 详情
(XIV) 31824 (6S,9R,12S,15S,18R,21S,24S)-15-[2-(benzyloxy)-2-oxoethyl]-6,9,18-triisobutyl-12-isopropyl-2,2-dimethyl-21-[(1S)-1-methylpropyl]-24-(10-methylundecyl)-4,7,10,13,16,19,22-heptaoxo-3,23-dioxa-5,8,11,14,17,20-hexaazahexacosan-26-oic acid C60H102N6O13 详情 详情
(XV) 31820 (2S)-5-amino-2-[(tert-butoxycarbonyl)amino]-5-oxopentanoic acid 13726-85-7 C10H18N2O5 详情 详情
(XVI) 31825 (6S,9S,12R,15S,18S,21R,24S,27S)-6-(3-amino-3-oxopropyl)-18-[2-(benzyloxy)-2-oxoethyl]-9,12,21-triisobutyl-15-isopropyl-2,2-dimethyl-24-[(1S)-1-methylpropyl]-27-(10-methylundecyl)-4,7,10,13,16,19,22,25-octaoxo-3,26-dioxa-5,8,11,14,17,20,23-heptaazano C65H110N8O15 详情 详情
(XVII) 31826 (3S,6S,9R,12S,15S,18R,21S,24S)-24,27-diamino-12-[2-(benzyloxy)-2-oxoethyl]-9,18,21-triisobutyl-15-isopropyl-6-[(1S)-1-methylpropyl]-3-(10-methylundecyl)-5,8,11,14,17,20,23,27-octaoxo-4-oxa-7,10,13,16,19,22-hexaazaheptacosan-1-oic acid C60H102N8O13 详情 详情
Extended Information