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【结 构 式】 
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【分子编号】31812 【品名】(E)-11-[(tert-butoxycarbonyl)amino]-15,15-dimethyl-2,13-dioxo-14-oxa-3,10,12-triaza-11-hexadecen-1-yl 4-(benzyl[(3R)-3-[(tert-butoxycarbonyl)amino]butyl]amino)butylcarbamate 【CA登记号】 |
【 分 子 式 】C40H69N7O9 【 分 子 量 】792.02964 【元素组成】C 60.66% H 8.78% N 12.38% O 18.18% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XVI)The resulting carboxylic acid (XIV) was coupled with the Boc-protected guanidinohexylamine (XV) using DCC and HOBt to produce amide (XVI). Finally, sequential deprotection of the N-benzyl group of (XVI) by hydrogenolysis, and then cleavage of the Boc groups by means of trifluoroacetic acid yielded the target compound.
| 【1】 Lebreton, L.; et al.; Structure - Immunosuppressive activity relationships of new analogues of 15-deoxyspergualin. 2. Structural modifications of the spermidine moiety. J Med Chem 1999, 42, 23, 4749. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (XIV) | 31811 | (6R)-9-benzyl-2,2,6-trimethyl-4,15-dioxo-3,16-dioxa-5,9,14-triazaoctadecan-18-oic acid | C23H37N3O6 | 详情 | 详情 | |
| (XV) | 22346 | tert-butyl (Z)-[(6-aminohexyl)amino][(tert-butoxycarbonyl)amino]methylidenecarbamate | C17H34N4O4 | 详情 | 详情 | |
| (XVI) | 31812 | (E)-11-[(tert-butoxycarbonyl)amino]-15,15-dimethyl-2,13-dioxo-14-oxa-3,10,12-triaza-11-hexadecen-1-yl 4-(benzyl[(3R)-3-[(tert-butoxycarbonyl)amino]butyl]amino)butylcarbamate | C40H69N7O9 | 详情 | 详情 | |
| (XVII) | 31813 | (E)-11-[(tert-butoxycarbonyl)amino]-15,15-dimethyl-2,13-dioxo-14-oxa-3,10,12-triaza-11-hexadecen-1-yl 4-([(3R)-3-[(tert-butoxycarbonyl)amino]butyl]amino)butylcarbamate | C33H63N7O9 | 详情 | 详情 |
Extended Information