• English
  • 简体中文
Login Register
Current Location: Home > Feedback Help Print

【结 构 式】

【分子编号】31794

【品名】(2-amino-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone

【CA登记号】

【 分 子 式 】C17H19NO5

【 分 子 量 】317.3416

【元素组成】C 64.34% H 6.03% N 4.41% O 25.21%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(I)

The 2-(chloromethyl)quinoline (III) was synthesized by Friedländer reaction of aminobenzophenone (I) with ethyl 4-chloroacetoacetate (II) in the presence of H2SO4 in AcOH at 100 C. Then, displacement of the halogen atom of (III) with the sodium salt of 1,2,4-triazole (IV) in DMF at 80 C afforded the target compound.

1 Baba, A.; et al.; Studies on disease-modifying antirheumatic drugs. III. Bone resorption inhibitory effects of ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate (TAK-603) and related compounds. Chem Pharm Bull 1999, 47, 3, 369.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 31794 (2-amino-4,5-dimethoxyphenyl)(3,4-dimethoxyphenyl)methanone C17H19NO5 详情 详情
(II) 23541 ethyl 4-chloro-3-oxobutanoate;Ethyl 4-chloro-3-oxobutanoate;Ethyl 4-chloroacetoacetate 638-07-3 C6H9ClO3 详情 详情
(III) 31795 ethyl 2-(chloromethyl)-4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-3-quinolinecarboxylate C23H24ClNO6 详情 详情
(IV) 13135 1H-1,2,4-Triazole; 1,2,4-Triazole 288-88-0 C2H3N3 详情 详情
Extended Information