【结 构 式】 |
【分子编号】31793 【品名】4-amino-2-bromophenol 【CA登记号】 |
【 分 子 式 】C6H6BrNO 【 分 子 量 】188.02378 【元素组成】C 38.33% H 3.22% Br 42.5% N 7.45% O 8.51% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号:(VII)4,5-Dimethoxy-2-nitrobenzoic acid (I) was treated with thionyl chloride to form acid chloride (II), followed by reaction with ammonia to yield 4,5-dimethoxy-2-nitrobenzamide (III). This was reduced with sodium borohydride in the presence of copper sulfate to give aminobenzamide (IV), which was refluxed with formic acid to afford 6,7-dimethoxyquinazoline-4(3H)-one (V). Subsequent treatment of (V) with phosphoryl chloride gave the chloroquinazoline (VI). The title compound was then prepared by condensation of (VI) with 2-bromo-4-aminophenol (VII) in refluxing ethanol.
【1】 Liu, X.-P.; Narla, R.K.; Uckun, F.M. (Parker Hughes Institute); Quinazolines for treating brain tumor. WO 9961428 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 31789 | 4,5-dimethoxy-2-nitrobenzoic acid | 4998-07-6 | C9H9NO6 | 详情 | 详情 |
(II) | 31790 | 4,5-dimethoxy-2-nitrobenzoyl chloride | C9H8ClNO5 | 详情 | 详情 | |
(III) | 31791 | 4,5-dimethoxy-2-nitrobenzamide | 4959-60-8 | C9H10N2O5 | 详情 | 详情 |
(IV) | 31792 | 2-amino-4,5-dimethoxybenzamide | 5004-88-6 | C9H12N2O3 | 详情 | 详情 |
(V) | 18684 | 6,7-dimethoxy-4(3H)-quinazolinone | 13794-72-4 | C10H10N2O3 | 详情 | 详情 |
(VI) | 23765 | 4-chloro-6,7-dimethoxyquinazoline; 4-chloro-6-methoxy-7-quinazolinyl methyl ether | C10H9ClN2O2 | 详情 | 详情 | |
(VII) | 31793 | 4-amino-2-bromophenol | C6H6BrNO | 详情 | 详情 |
Extended Information