methyl 2-[(1R,2S)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-yl]acetate -Drug Synthesis Database

【结构式】

【分子编号】31780

【品名】methyl 2-[(1R,2S)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-yl]acetate

【CA登记号】

【分子式】C₂₁H₂₄ClNO₃

【分子量】373.8792

【元素组成】C 67.46% H 6.47% Cl 9.48% N 3.75% O 12.84%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XIII)

Alternatively, nitrile (VIII) was converted to ester (XIII) upon treatment with H2SO4 and MeOH. Ester reduction employing lithium borohydride afforded alcohol (XIV). This was chlorinated with PCl5 and then cyclized and demethylated using AlCl3.

参考文献中间体

合成目标

【1】 Wu, G.; et al.; Amino diol based asymetric syntheses of a fused benzazepine as a selective D1 dopamine receptor. Org Process Res Dev 1997, 1, 5, 359.

中间体序号	中间体编号	品名	分子式	供应商	用于合成
(VIII)	31775	2-[(1R,2S)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-yl]acetonitrile	C₂₀H₂₁ClN₂O	详情	详情
(XIII)	31780	methyl 2-[(1R,2S)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-yl]acetate	C₂₁H₂₄ClNO₃	详情	详情
(XIV)	31781	2-[(1R,2S)-7-chloro-8-methoxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-2-yl]-1-ethanol	C₂₀H₂₄ClNO₂	详情	详情

Extended Information