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【结 构 式】 
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【分子编号】31715 【品名】5H-dibenzo[a,d]cyclohepten-5-one O-[2-(dimethylamino)ethyl]oxime 【CA登记号】 |
【 分 子 式 】C19H20N2O 【 分 子 量 】292.38068 【元素组成】C 78.05% H 6.89% N 9.58% O 5.47% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)By decomposition of O-beta-(N-methyl-N-carbethoxy)aminoethyl-5H-dibenzo[a,d]cyclohepten-5-one oxime (III) with KOH in carbitol. Compound (III) can be prepared as follows: 5H-ibenzo[a,d]cyclohepten-5-one oxime (I) is treated with beta-dimethylaminoethyl chloride (IV) in sodium methoxide to give O-beta-dimethylaminoethyl-5H-dibenzo[a,d]cyclohepten-5-one oxime (V), which is treated with ethyl chlorocarbonate in anhydrous benzene.
| 【1】 Pirola, O.; Rossi, S.; Fanelli, O.; Maggi, R.; O- And N- substituted 5H-dibenzo[a,d]cyclohepten-5-one oximes with thymoleptic acticity. VII. Synthesis and pharmacological properties of the substituted oximes. Farm Sci Ed 1969, 24, 7, 685-703. |
| 【2】 Castaner, J.; Serradell, M.N.; Blancafort, P.; Demexiptiline hydrochloride. Drugs Fut 1982, 7, 1, 19. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 31713 | 5H-dibenzo[a,d]cyclohepten-5-one oxime | C15H11NO | 详情 | 详情 | |
| (III) | 31716 | ethyl 2-[(5H-dibenzo[a,d]cyclohepten-5-ylideneamino)oxy]ethyl(methyl)carbamate | C21H22N2O3 | 详情 | 详情 | |
| (IV) | 11907 | Dimethylaminoethyl chloride; 2-Dimethylaminoethyl chloride; 2-Chloro-N,N-dimethyl-1-ethanamine; N-(2-Chloroethyl)-N,N-dimethylamine | 107-99-3 | C4H10ClN | 详情 | 详情 |
| (V) | 31715 | 5H-dibenzo[a,d]cyclohepten-5-one O-[2-(dimethylamino)ethyl]oxime | C19H20N2O | 详情 | 详情 |
Extended Information